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Neuroimmunity and Neuroinflammation

  • The body responds to insult or injury by engaging the immune system

  • The immune cells of the brain, microglia and mast cells, coordinate with astrocytes to contain insults and assist in brain repair, by releasing:

    • Prostaglandins

    • Cytokines

    • Free radicals

    • growth factors

  • During development of the male medial preoptic area (mPOA)- a region crucial for expression of male sex behavior, males rats have significantly more active microglia than females

    • A masculinizing dose of estradiol at given to female rats at birth both increases the number and activation state to that of males.